Telocollagen vs Atelocollagen

Collagen gelation and gel stiffness are strongly affected by pH, molecular composition (Atelocollagen vs Telocollagen), concentration, ionic strength, ingredient quality, temperature and working conditions (time, mixing).

This post will demonstrate the differences between Telocollagen and Atelocollagen.


Collagen is typically extracted from a wide variety of sources, such as cow hide, rat tails, or porcine tendon, to name a few. Typically, you can extract the collagen using acid, or with an enzyme.


Collagen extracted with acid will result in Telocollagen - meaning it has the telopeptide portion of the collagen molecule intact. When extracted using an enzyme, the molecule is cleaved at the junction of the triple-helix domain and the telopeptide. The resulting collagen is known as Atelocollagen (without the telopeptide).


Gelation Differences between Telocollagen and Atelocollagen


The graph below shows three collagen products at similar concentrations, and their resulting 3D hydrogel stiffness. TeloCol® is a 3 mg/ml type I collagen extracted from bovine hide using acid. RatCol® is a 4 mg/ml type I collagen extracted from rat tail using acid. PureCol® is a 3 mg/ml type I collagen extracted from bovine hide using enzymes.

The results for Atelocollagen compared to Telocollagen indicate that collagen with the Telo-peptide portion of the collagen molecule intact polymerizes more rapidly and forms stiffer gels than Atelocollagen.


The following information is summarized in the YouTube video, below:

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The products referenced in this post are:

PureCol® - type I collagen, bovine, 3 mg/ml, atelocollagen

TeloCol® - type I collagen, bovine, 3 mg/ml, telocollagen

RatCol® - type I collagen, rat tail, 4 mg/ml, telocollagen

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