Applications of Lifeink® 400 Methacrylated Hyaluronic Acid


Methacrylated Hyaluronic acid (also known as PhotoHA® or Lifeink® 400) can be used to form hydrogels for ex-vivo engineering of autologous cartilage tissue[1] or as a mesenchymal stem cell carrier in cartilage repair[2].

Because the stiffness can be widely adjusted by altering concentration or UV-light exposure, methacrylated HA has been used to measure the effects of matrix stiffness on cell phenotype and function[3][4].

Methacrylated HA can be used for 3D bioprinting (extrusion[5], inkjet[5] and photolithographic[6]) to create structures that promote osteogenic differentiation of MSC’s[7].

The high tunability of hyaluronic acid methacrylate allows it to be mixed with, and reinforce other types of hydrogels (such as collagen, or gelatin methacrylate)[8].

References:

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717235/

  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627486/

  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541838/

  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447944/

  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615317/

  6. https://www.ncbi.nlm.nih.gov/pubmed/21773726/

  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460858/

  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748291/

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